Evaluation of Hemostatic Effectiveness in a Standard Swine Hemorrhage Model of Severe Bleeding: A Comparative Study of Chitosan Gauze and Kaolin Gauze
Publication Details:
Kumar A, Agrawal A, Bharani KK, Mavely L. Evaluation of Hemostatic Effectiveness in a Standard Swine Hemorrhage Model of Severe Bleeding: A Comparative Study of Chitosan Gauze and Kaolin Gauze. International Journal of Health Technology and Innovation. 2024 Aug 20;3(02):38-47.
Key Findings and Data:
Superior Hemostasis Efficacy and Improvement of Survival Rate

- Axiostat gauze significantly reduce the post treatment blood loss by more than 80% as compared to Kaolin gauze (P<0.05).
- Axiostat gauze also demonstrated 100 % survival rate and improves the survival rate by 67 % than kaolin gauze.
Antimicrobial Efficacy of Axiostat Gauze

- After 24 hours of contact time, Axiostat gauze showed more than 99.99% reduction of viable microorganisms against all the pathogenic microbial strains. Kaolin gauze has no antimicrobial property.
Key Insights
- Axiostat gauze has a superior safety profile compared to kaolin gauze as indicated by the absence of particle release.
- Axiostat gauze delivers faster hemostasis, reduces overall blood loss significantly, and improve the survival rate in comparison to kaolin gauze.
- Axiostat gauze is an effective hemostatic dressing with additional benefits, including antimicrobial properties and biocompatibility, making it suitable for managing severe bleeding in emergency and trauma scenarios.
- Axiostat gauze is highly recommended for use in both military and civilian prehospital settings as a strategic approach to effectively address critical bleeding.