Severe bleeding is one of the most critical emergencies in trauma and surgical care. Rapid and effective bleeding control can be the difference between life and death. Traditional methods like manual compression with gauze can be time-consuming and less effective, especially in high-risk patients, such as those on anticoagulants or with underlying conditions like diabetes and hypertension.

In recent years, chitosan-based hemostatic dressings have emerged as a breakthrough in wound management. Axiostat, a 100% chitosan wound dressing, has been clinically proven to stop severe bleeding in various medical scenarios, from emergency trauma to surgical interventions. This blog explores how Axiostat’s hemostatic dressing technology is transforming trauma care, supported by a case study demonstrating its impact in a pacemaker implantation procedure.

The Need for Rapid Bleeding Control in Trauma

Excessive bleeding, if not controlled immediately, can lead to serious complications, including hypovolemic shock, organ failure, and increased mortality. Traditional hemostatic techniques involve applying pressure with gauze, which can take 15–20 minutes to achieve adequate bleeding control. This delay can be detrimental in situations where every second counts.

Chronic conditions such as diabetes and hypertension add another layer of complexity. These conditions can impair the body’s natural clotting ability, increasing the risk of prolonged bleeding and post-procedure complications. In such cases, a more advanced and rapid-acting wound dressing is necessary to minimize risks and improve patient outcomes.

How Chitosan Hemostatic Dressings Work

Chitosan is a naturally derived biopolymer with unique bioadhesive and hemostatic properties. Axiostat’s chitosan wound dressing utilizes Protonated Bioadhesive Technology (PBT®), which enhances its ability to control bleeding efficiently.

Mechanism of Action

• Charge-based clotting activation: Axiostat interacts with blood components at the molecular level. The positively charged chitosan binds to negatively charged blood cells, forming a rapid seal at the wound site.
• Instant adherence: Unlike conventional gauze, which absorbs blood passively, chitosan actively participates in clot formation, significantly reducing the time required for hemostasis.
• Effectiveness on anticoagulated patients: Since Axiostat does not depend on the body’s natural clotting mechanisms, it is particularly useful for patients on blood thinners.
• Painless removal: Once hemostasis is achieved, Axiostat can be easily removed using saline irrigation, without disrupting the formed clot.

These features make Axiostat a valuable tool in trauma management, emergency medicine, and surgical procedures.

Clinical Case Study: Axiostat in Pacemaker Implantation

A recent clinical case from NH MMI Hospital, Raipur, India, provides compelling evidence of Axiostat’s effectiveness in surgical bleeding control. The study involved a 44-year-old female patient undergoing a permanent pacemaker implantation procedure.

Case Details

• Medical history: Diabetes & hypertension
• Procedure: Pacemaker implantation
• Axiostat Variant Used: V55
• Time Taken for Hemostasis: 3 minutes

Case Description

During the pacemaker implantation, a pocket was created in the chest, leading to profuse bleeding. Conventional gauze compression would typically take 15–20 minutes to achieve hemostasis, increasing the risk of complications. Instead, Axiostat V55 was applied, and complete hemostasis was achieved in just 3 minutes.

Key Findings

• No re-bleeding was observed at the puncture site.
• No skin irritation, swelling, or vascular complications were reported after the procedure.
• No device-related bleeding complications occurred for five days post-surgery.
• The surgical site remained clear, allowing the procedure to continue without any disturbance.

This case demonstrates how Axiostat significantly reduces bleeding time, enhances patient safety, and improves overall procedural efficiency.

Advantages of Chitosan-Based Hemostatic Dressings Over Traditional Gauze

When compared to conventional gauze-based hemostatic agents, Axiostat’s chitosan wound dressing offers several advantages:

These benefits make Axiostat the preferred choice for trauma care, surgical applications, and emergency medicine.

Applications of Chitosan Hemostatic Dressings in Trauma & Surgery

1. Emergency Trauma & EMS

Axiostat is widely used in pre-hospital emergency care to manage severe bleeding from gunshot wounds, road accidents, and deep lacerations. Its rapid action helps stabilize patients before reaching a hospital.

2. Military & Tactical Medicine

Designed for battlefield use, Axiostat is vacuum-sealed in rugged packaging, ensuring its effectiveness even in extreme conditions. It is NSN codified and approved for use in combat situations where bleeding control is critical.

3. Vascular Closure & Catheterization

Axiostat is particularly effective in vascular procedures, such as angioplasty and catheterization, where quick and reliable hemostasis is required.

4. Burn Wound Care

Axiostat’s antimicrobial and hydrobalancing properties make it suitable for burn wounds, preventing infections and promoting faster recovery.

5. Chronic Wound Management

Chitosan wound dressings are also used in treating diabetic foot ulcers, pressure ulcers, and surgical wounds, providing enhanced wound healing and exudate management.

The Future of Bleeding Control with Chitosan Hemostatic Dressings

As demonstrated in the pacemaker implantation case study, Axiostat significantly reduces bleeding time, minimizes post-procedure complications, and enhances overall patient recovery.

The growing adoption of chitosan wound care solutions in trauma, surgery, and emergency medicine is transforming how healthcare professionals manage bleeding. Compared to traditional gauze-based methods, Axiostat’s advanced hemostatic technology provides a faster, safer, and more effective alternative.

With its proven clinical efficacy, ease of use, and versatility, Axiostat continues to set new standards in bleeding control and wound care management.

For more information on Axiostat’s life-saving technology, visit www.axiostat.com